Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation.
Maeda F; Keenan JP; Pascual-Leone A
Br J Psychiatry 2000 Aug;177:169-73

ABSTRACT: Neuroimaging studies of major
depressive disorder (MDD) indicate interhemispheric
differences in prefrontal cortical activity (right greater
than left). AIMS: To investigate whether there are
any interhemispheric differences of motor cortical
excitability in MDD. METHOD: Eight patients with
treatment-refractory MDD off medication were
assessed for the severity of their depression, and
transcranial magnetic stimulation studies (bilateral
motor threshold and paired-pulse studies) were
conducted. Eight normal controls were also studied.
RESULTS: MDD patients showed significant
interhemispheric differences in motor threshold and
paired-pulse curves, both of which showed lower
excitability on the left hemisphere. Such differences
were absent in controls. CONCLUSIONS: Our
findings may aid the further understanding of the
neurophysiology underlying MDD.

MAIN MESH HEADINGS:
Depression, Involutional/*physiopathology
Magnetics/*diagnostic Use
Motor Cortex/*physiology
ADDITIONAL MESH
HEADINGS:
Adult
Aged
Depression, Involutional/diagnosis
Depression, Involutional/etiology
Electric Stimulation/methods
Female
Human
Male
Middle Age
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
2000/10
2000/21 11:01
PUBLICATION TYPES:
JOURNAL ARTICLE
LANGUAGES:
Eng
GRANT/CONTRACT ID:
RO1MH57980/MH/NIMH

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Eletromagnetismo

Bioeletricidade
em Psiquiatría