How coil-cortex distance relates to age, motor threshold, and antidepressant response to repetitive transcranial magnetic stimulation.
Kozel FA; Nahas Z; deBrux C; Molloy M; Lorberbaum JP; Bohning D; Risch SC; George MS
J Neuropsychiatry Clin Neurosci 2000 Summer;12(3):376-84

ABSTRACT: Repetitive transcranial magnetic stimulation (rTMS) is a
tool with antidepressant potential that uses a coil placed
on the scalp to produce a powerful magnetic field that
directly stimulates only the outermost cortex. MRI scans
were obtained in 29 depressed adults involved in an rTMS
antidepressant clinical treatment. These scans were
analyzed to investigate the effect of distance from coil to
cortex on clinical parameters. Longer motor cortex
distance, but not prefrontal distance, strongly correlated
with increased motor threshold (P<0.01). Clinical
antidepressant response did not correlate with either
distance. The rTMS antidepressant responders, however,
were significantly younger (t=-2.430, P<0.05), and there
appears to be a maximum threshold of age and distance to
prefrontal cortex for response.


MAIN MESH
HEADINGS:
Antidepressive Agents/*therapeutic Use
Depressive Disorder/*drug Therapy
Electromagnetics/*methods
Motor Cortex/*anatomy & Histology
Prefrontal Cortex/*anatomy & Histology
ADDITIONAL MESH
HEADINGS:
Adult
Age Factors
Depressive Disorder/diagnosis
Double-Blind Method
Female
Human
Magnetic Resonance Imaging
Male
Middle Age
Motor Cortex/radionuclide Imaging
Prefrontal Cortex/radionuclide Imaging
Psychiatric Status Rating Scales
Skull
Support, Non-U.S. Gov't
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
2000/10
2000/07 11:01
PUBLICATION TYPES:
CLINICAL TRIAL
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
CAS REGISTRY
NUMBERS:
0 (Antidepressive Agents)
LANGUAGES: Eng

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Eletromagnetismo

Bioeletricidade
em Psiquiatría