Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation [In Process Citation]
Nitsche MA; Paulus W
J Physiol 2000 Sep 15;527 Pt 3:633-9 [MEDLINE record in process]

ABSTRACT: In this paper we demonstrate in the intact human the
possibility of a non-invasive modulation of motor cortex
excitability by the application of weak direct current
through the scalp. Excitability changes of up to 40 %,
revealed by transcranial magnetic stimulation, were
accomplished and lasted for several minutes after the end
of current stimulation. Excitation could be achieved
selectively by anodal stimulation, and inhibition by
cathodal stimulation. By varying the current intensity and
duration, the strength and duration of the after-effects
could be controlled. The effects were probably induced by
modification of membrane polarisation. Functional
alterations related to post-tetanic potentiation, short-term
potentiation and processes similar to postexcitatory
central inhibition are the likely candidates for the
excitability changes after the end of stimulation.
Transcranial electrical stimulation using weak current may
thus be a promising tool to modulate cerebral excitability
in a non-invasive, painless, reversible, selective and focal
way.

ADDITIONAL MESH
HEADINGS:
2000/09
2000/16 11:00
LANGUAGES:
Eng

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Eletromagnetismo

Bioeletricidade
em Psiquiatría