Effects of chronic levodopa and pergolide treatment on cortical excitability in patients with Parkinson's disease: a transcranial magnetic stimulation study.
Strafella AP; Valzania F; Nassetti SA; Tropeani A; Bisulli A; Santangelo M; Tassinari CA
Clin Neurophysiol 2000 Jul;111(7):1198-202

PMID: 10880793 UI: 20342744
ABSTRACT:
OBJECTIVES: : Transcranial magnetic stimulation was
used to assess the effects of chronic levodopa and
pergolide treatment on motor cortex excitability in
Parkinson disease (PD). METHODS: Motor thresholds,
intracortical inhibition and facilitation were studied at
baseline and after 6 and 12 months of therapy in 10 PD
patients and compared to 7 age-matched controls.
RESULTS: At baseline, there was significantly less
intracortical inhibition with only a slight reduction of
intracortical facilitation in PD as compared to controls.
Relative to pretreatment condition, levodopa restored
intracortical inhibition for 12 months while pergolide did
not. Intracortical facilitation was always within the normal
range. Motor thresholds were unchanged in both groups of
patients over 12 months. Clinically, levodopa and
pergolide improved motor Unified Parkinson's disease
rating scale (UPDRS) scores at 6 months but only
levodopa maintained benefit at 12 months as compared to
baseline. CONCLUSIONS: Levodopa and pergolide
differentially affected cortical inhibitory circuits at 12
months. The progressive deterioration of restored
intracortical inhibition with pergolide may be due to the
development of tolerance and down-regulation of
dopamine receptors.

MAIN MESH
HEADINGS:
Levodopa/*administration & Dosage
*Magnetics
Motor Cortex/*drug Effects
Parkinson Disease/*drug Therapy
Pergolide/*administration & Dosage
ADDITIONAL MESH
HEADINGS:
Aged
Analysis Of Variance
Drug Administration Schedule
Drug Therapy, Combination
Electric Stimulation/instrumentation
Human
Middle Age
Motor Cortex/physiopathology
Neural Inhibition/drug Effects
Parkinson Disease/physiopathology
Reaction Time/drug Effects
Sensory Thresholds/drug Effects
Severity Of Illness Index
2000/09
2000/19 11:01
PUBLICATION TYPES:
CLINICAL TRIAL
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
CAS REGISTRY
NUMBERS:
0 (Levodopa)
66104-22-1 (Pergolide)
LANGUAGES:
Eng

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Eletromagnetismo

Bioeletricidade
em Psiquiatría