Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation.
Mottaghy FM; Krause BJ; Kemna LJ; Topper R; Tellmann L; Beu M; Pascual-Leone A; Muller-Gartner HW
Neurosci Lett 2000 Feb 25;280(3):167-70

ABSTRACT:
We Studied The Effect Of Repetitive Transcranial Magnetic
Stimulation (rTMS) On Changes In Regional Cerebral
Blood Flow (rCBF) As Revealed By Positron Emission
Tomography (PET) While Subjects Performed A 2-back
Verbal Working Memory (WM) Task. RTMS To The Right
Or Left Dorsolateral Prefrontal Cortex (DLPFC), But Not To
The Midline Frontal Cortex, Significantly Worsened
Performance In The WM Task While Inducing Significant
Reductions In RCBF At The Stimulation Site And In Distant
Brain Regions. These Results For The First Time
Demonstrate The Ability Of RTMS To Produce Temporary
Functional Lesions In Elements Of A Neuronal Network Thus
Changing Its Distributed Activations And Resulting In
Behavioral Consequences.
MAIN MESH HEADINGS:
Brain/*physiology
*Brain Mapping
Cerebrovascular Circulation/*physiology
*Magnetics
Memory/*physiology
Neurons/*physiology
PUBLICATION TYPES: JOURNAL ARTICLE
LANGUAGES: Eng

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Eletromagnetismo

Bioeletricidade
em Psiquiatría