Lasting cortical activation after repetitive TMS of the motor cortex: a glucose metabolic study.
Siebner HR; Peller M; Willoch F; Minoshima S; Boecker H; Auer C; Drzezga A; Conrad B; Bartenstein P
Neurology 2000 Feb 22;54(4):956-63

ABSTRACT:
OBJECTIVE: Cerebral [18F]fluorodeoxy-D-glucose PET
([18F]FDG-PET) Was Used To Visualize The Lasting Neuronal
Activation After Repetitive Transcranial Magnetic Stimulation
(rTMS) Over The Left Hand Area Of The Primary Motor Cortex
(M1HAND). BACKGROUND: Applied Over M1HAND, RTMS
Has Been Shown To Produce A Modulation Of Corticomotor
Excitability Beyond The Time Of Stimulation Itself. METHODS:
Eight Right-handed Subjects Underwent Nonquantitative
[18F]FDG-PET Measurements During Two Experimental
Conditions: At Rest And After Focal Subthreshold 5-Hz RTMS Over
The Left M1HAND. In The Post-rTMS Condition, [18F]FDG Was
Injected Immediately After The Administration Of 1,800 Magnetic
Pulses Over The Left M1HAND. Relative Differences In
Normalized Regional Cerebral Metabolic Rate Of Glucose
(normalized RCMRglc) Between Conditions Were Determined
Using A Voxel-by-voxel Student's T-test And Volume-of-interest
(VOI) Analysis. Analysis Was A Priori Restricted To The
M1HAND, The Supplementary Motor Area (SMA), And The
Primary Auditory Cortex Of Both Hemispheres. RESULTS: A
5-Hz RTMS Of The Left M1HAND Caused A Lasting Relative
Increase In Normalized RCMRglc Within The M1HAND
Bilaterally And The SMA. The Magnitude And The Topographic
Pattern Of Persisting Relative RCMRglc Increases Within These
Motor Cortical Areas Demonstrated Considerable Interindividual
Variations. CONCLUSIONS: Subthreshold 5-Hz Repetitive
Transcranial Magnetic Stimulation (rTMS) Over The Hand Area Of
The Primary Motor Cortex Is Associated With A Persisting
Neuronal Activation In A Distinct Set Of Motor Cortical Areas
Beyond The Time Of Stimulation. The Current Findings
Demonstrate That [18F]FDG-PET Can Localize And Quantify
Regional Net Changes In Synaptic Cortical Activity After RTMS And
Thus Might Elucidate The Mechanisms Underlying
RTMS-associated Therapeutic Effects.
MAIN MESH
HEADINGS:
*Magnetics
Motor Cortex/*physiology
Motor Cortex/*radionuclide Imaging
PUBLICATION TYPES:
JOURNAL ARTICLE
LANGUAGES: Eng

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Eletromagnetismo

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