Therapeutic and
Mally J; Stone TW
J Neurosci Res 1999 Sep 15;57(6):935-40

ABSTRACT: Transcranial Magnetic Stimulation (TMS) Has Been Used In The Diagnosis Of Neurological Lesions And Has Been Introduced Into The Therapy Of Central Nervous Diseases. Lately It Has Been Claimed That TMS Would Be Useful Not Only In The Treatment Of Depression, But Also In Relieving Symptoms Of Parkinson's Disease. In This Study, We Sought Evidence Of The Effect Of Repetitive TMS On The Symptoms Of Parkinson's Disease, The Dose Dependency Between The Applied Elecromagnetic Field And The Parkinsonian Symptoms, And The Maintenance Of The Improvement. Forty-nine Patients With Parkinson's Disease Were Divided Into Four Groups, Each Given One Stimulus, Repeated 30 Times, Once Or Twice A Day ( Approximately 0.34Tesla (T), Approximately 0.57T, Approximately 0.80T). Patients Were Followed For 3 Months And Assessed Using Two Different Parkinsonian Scales: The Graded Clinical Rating Scale And Unified Parkinson Disability Rating Scale (UPDRS), And With A Short-term Memory Test (Ziehen-Ranschburg Word Pair Test). No Effect Was Seen In The Group Treated With Approximately 0.34T30 Stimuli Once A Day. In All Of The Groups Receiving TMS Twice A Day, The Parkinsonian Scores Were Significantly Decreased Compared With That Of Baselines After 1 Month Of Treatment. The Greatest Improvement In The Hypokinesia Was Detected In The Group Treated With Approximately 0.57T30 Stimuli Twice A Day (baseline Total UPDRS: 30.62 +/- 15.23; 1 Month After Treatment: 17.08 +/- 7.04, P < 0.01; 3 Months After Treatment: 16.08 +/- 7.06, P < 0.01). A Dose-dependent Difference Was Observed Between The Two Groups After 3 Months. The Total UPDRS In Group II ( Approximately 0.34T30 Stimuli Twice A Day) Significantly Differed From Group III ( Approximately 0.57T30 Stimuli Twice A Day; 22.43 +/- 8.87, 16.08 +/- 7.06, P < 0.05). The Long-lasting Improvement Effect With TMS Would Seem To Suggest It As An Appropriate Tool In The Therapy Of Parkinson's Disease. Copyright 1999 Wiley-Liss, Inc.
MAIN MESH HEADINGS:
*Electroconvulsive Therapy
*Electromagnetic Fields
Parkinson Disease/*therapy

PUBLICATION TYPES:
CLINICAL TRIAL
CONTROLLED CLINICAL TRIAL
JOURNAL ARTICLE
LANGUAGES: Eng

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Eletromagnetismo

Bioeletricidade
em Psiquiatría