[Poster Session III: Basic Neuropharmacology; Clinical Neuropharmacology; Clinical Neurophysiology][3.117] Cortical Excitability In Progressive Myoclonus Epilepsies: A Polygraphic And Transcranial Magnetic Stimulation Study
Franco Valzania, Antonio Strafella, Andrea Tropeani, Stefania Nassetti, Guido Rubboli, Carlo A. Tass
.

Rationale:
To Investigate Cortical Excitability In Progressive Myoclonus Epilepsies (PME), By Means Of Polygraphic Techniques And
Transcranial Magnetic Stimulation (TMS). Methods: 12 Patients With PME And 8 Normal Subjects Were Investigated. TMS Was
Performed By Delivering Paired Magnetic Stimuli At Interstimulus Interval (ISI) Ranging From 50 To 200 Msec And At Stimulus Intensity
Of 10% Above Threshold. Modulation Of The Area Of The Test Motor Evoked Potential (MEP) Was Expressed As Percentage Of
Conditioning MEP (100%). EEG-EMG Correlation Was Performed In 1000 Msec Epochs By Means Of A 21 -channel Computerized
Polygraphic System.

Results:
Paired TMS Showed A Significant Facilitation (p)

Conclusions:
Our Data Demonstrate, In PME, An Increased Excitability Of The Motor System, Occurring At A Supraspinal, Cortical Level.

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Eletromagnetismo

Bioeletricidade
em Psiquiatría