High frequency transcranial magnetic stimulation mimics the effects of ECS in upregulating astroglial gene expression in the murine CNS.
Fujiki M; Steward O
Brain Res Mol Brain Res 1997 Mar;44(2):301-8

ABSTRACT:
The Present Study Evaluates The Consequences Of High
Frequency (25 Hz) Trans-cranial Magnetic Stimulation On The
Expression Of Glial Fibrillary Acidic Protein (GFAP) In The
Murine CNS. Trains Of Transcranial Magnetic Stimulation
(1-30 Trains At 25 Hz, 10 S Duration) Were Delivered To Mice
Via 5-cm Diameter Round Coils. The Stimulation Produced
Stimulus-locked Motor Responses But Did Not Elicit
Behavioral Seizures. GFAP MRNA Levels Were Evaluated 12,
24, 36, 48 H, 4 Days, And 8 Days Following Stimulation By In
Situ Hybridization. Following Multiple 25 Hz Trains, There
Were Dramatic Increases In The Levels Of GFAP MRNA In The
Hippocampal Dentate Gyrus; More Modest Increases Were
Observed In The Cerebral Cortex. The Selective Increases In
GFAP MRNA In The Dentate Gyrus Were Similar To Those
Observed Following Single Electroconvulsive Seizures (ECS).
These Results Indicate That Trans-cranial Magnetic
Stimulation Can Be Used To Modulate Astroglial Gene
Expression, Inducing The First Stage Of A Reactive Response
That Is Similar To What Occurs Following Nervous System
Injury.
MAIN MESH
HEADINGS:
Astrocytes/*metabolism
Cerebral Cortex/*physiology
*Electroconvulsive Therapy
Gene Expression Regulation/*physiology
*Magnetics
PUBLICATION TYPES:
JOURNAL ARTICLE
CAS REGISTRY NUMBERS:
0 (Glial Fibrillary Acidic Protein)
LANGUAGES: Eng
GRANT/CONTRACT ID: NS 29875/NS/NINDS

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Eletromagnetismo

Bioeletricidade
em Psiquiatría